The Biden Administration plans to offer a second booster shot to 50 and up

WASHINGTON – The Biden administration is planning to give Americans 50 years of age and older the option of another booster for the Pfizer-BioNTech or Moderna Corps virus vaccine without recommending that they get one, with many familiar with the project. According to.

The widespread uncertainty complicates the decision, including how long a second booster protection will last, how to explain the project to the public and whether the overall goal is to save Americans from serious illness or less serious. Also from infection, because they. Long can cause coding.

Much depends on when the next wave of cod infection hits, and how severe. Should the nation suffer a catastrophic surge in the next few months, offering yet another booster for older Americans could save thousands of lives and prevent thousands of hospitals.

But if the fall does not seem like a big leap, the extra shot may now prove to be a questionable intervention that destroys vaccine medications, increases vaccine fatigue, and raises doubts about the government’s strategy. The highly regarded Omicron subvariant BA.2 is helping drive another expansion of the Corona virus cases in Europe, and is responsible for a third of new cases in the United States, but health officials say they expect major growth due to the suburban. Do not expect General Chat Chat Lounge

Federal health officials have warmly discussed the path forward, with some vigorously now favoring both Booster and others skeptical. But they’ve apparently come together around a plan to give everyone up to the age of 50 and an option for an extra shot, in case the infection is recaptured before fall. In the fall, officials say, Americans of all ages, including anyone who gets a booster this spring, should take another shot.

The Food and Drug Administration could authorize another booster early next week, according to many who are familiar with the idea. The Centers for Disease Control and Prevention will then follow up with their own advice.

Another booster is at best a stopgap measure. Many experts argue that existing corona virus vaccines need to be replaced because different types of viruses reduce their potency; The question is how to rearrange them. The increase in fall is most likely considered, whether it comes in the form of the Omicron variant, a subvariant such as BA.2 or a completely new series.

More than a dozen studies are underway to find the next generation of vaccines, with the first results expected in May or June. If all goes well, it will be enough time to produce new medicines before the fall. One major obstacle is that the Biden administration says it doesn’t have the money it needs to align its position with vaccine manufacturers already paying the doses.

In addition, data from the CDC shows that four to five months after the third shot, Pfizer-BioNTech and Moderna vaccines remain approximately 78 percent effective against hospitalization due to code-19. This may be a rough estimate, given the limitations of the study.

On the other hand, 78% is still less than 91%, which was found two months later, and the power of the vaccine may decrease over time. If a new wave emerges in the coming months, a slight reduction in hospitalization protection could have a big impact, especially for about 55 million Americans 65 or over who are currently suffering from epidemic disease. The others are Pfizer and BioNTech said rising data, including those from Kaiser Permanente, shows that their booster dose strength against chronic illness expires in three to six months.

Already, one in 75 Americans has died of quotient 65 or older, according to CDC data, which accounts for three-fourths of the nation’s death from the virus. More than 33 million people in that age group, or more than two-thirds, have received a first booster and will be eligible for a second.

For some officers, the bottom line is the question: How effective should a booster be against the drop in hospital admission before being justified?

As it was in the fall, when boosters were first fired, the wider scientific community divided what to do. “I’m not convinced that there is a significant reduction in protection against acute illness after the third dose,” Dr. Philip Cross, a former senior regulator at the FDA, said in an interview.

But Dr. Monica Gandhi, an obstetrician doctor and medical professor at the University of California, San Francisco, said that when healthy young people were okay with a booster, older people “probably should start taking a fourth shot.”

There may be a slight resistance among scientists now compared to the first booster shot, as evidence has shown that these medications can save lives during the winter omakroon wave.

Considering the limited nature of the data supporting the second round of booster shots, some federal officials say some kind of neutral advice is as far as the Biden administration can go. But generally, desire-wash regulatory advice is not as popular, as people and physicians often seek concrete advice over alternatives.

Dr. John E. Ehberg, chief of the Division of Infectious Diseases at Mount Sinai’s Health System, said the public can be disappointed with just another booster’s permission.

Unlike the first round of regulatory decisions on booster shots, meetings of any FDA or CDC advisory committees have not been planned prior to the decision on both boosters. Panel recommendations are non-binding but generally follow up. These committees will be criticized for neglect.

“This is a complex decision that involves a lot of ghosts, and I think it will really benefit from public debate,” said Dr. Jesse L. Goodman, former FDA chief scientist. “I do not want to see the advisory committee. General Chat Chat Lounge Give it a go.

But management officials seem ready to accept complaints about the process. The FDA has scheduled its advisory committee meeting on April 6 to discuss how the administration’s overall vaccine strategy should go.

Over time, federal officials are only doing their best. If people now get another booster and the virus re-emerges in July, their protection is already gone. On the other hand, if the administration waits until the wave of cod runs, it will be too late to vaccinate millions of people.

Supply appears: States have 131 million bouts of Pfizer-BioNTech and Moderna vaccine. Many experts say there is no evidence that an extra shot can damage people’s immune systems by making them habitual coronavirus vaccines.

The biggest disadvantages can be the vaccine fatigue and the suspicion that the vaccine works and the nation’s vaccine policy is really driven by data. With each successive shot that becomes available, fewer Americans get it.

In addition to the CDC, the United Kingdom and Israel have put data on the effectiveness of booster shot reduction. A recent report from the UK Healthcare Agency states that the efficacy against symptomatic infections can be reduced between 25% and 40% after 15 weeks or after the booster dose of Pfizer or Moderna.

The British Health Agency said it was difficult to measure the extent to which boosters protect against hospitalization. Whereas Omicron usually causes more common illnesses than previous variants, more hospitalized patients were tested positive for COD but were admitted for other reasons.

Looking at patients admitted for respiratory disease only, the agency estimates that the efficacy of vaccine against hospitalization for those 65 and older was reduced by 85% 15 weeks or more after booster, the week after the shot. Compared to 91%. Like the threats from other countries, the United Kingdom is offering another booster this spring to put older people and others at greater risk.

Israeli data shows that another booster shot increases the protection against hospital admissions four times and twice against infections. But nobody knows how long it is. Since Israel recently launched its D-Booster campaign, it has data for just two months or less. Other Israeli data suggest that another booster restores the level of antibodies to the top level after the first booster, but Dr. Eberg said the data set, too, had limitations.

A study conducted on Thursday of more than half a million Israelis found a significant reduction in mortality among people 60 and older who received second booster compared to those who received only the first. This research has generated strong interest among some vaccine specialists but has not been peer-reviewed.

Pfizer and Moderna don’t seem to have much of their own data to support their emergency authority requests. Pfizer is looking for another booster for those 65 and older, while Moderna filed a clean request to offer a second booster shot to all adults. No data is from a randomized, placebo-controlled study – considered to be the gold standard of scientific evidence – depending on how the dose works.

“We have to make this decision based on incomplete information,” said Dr. Peter J. Hotz, a vaccine specialist at Baylor College of Medicine in Houston.

Sheilag McNeill And Katie Bennett Contribute to the research.

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