It was a small trial, with only 18 rectal cancer patients, every one who took the same drug.
But the results were astonishing. The cancer is vanished into every single patient, undetectable by physical examination, endoscopy, PET scans or MRI scans.
Dr. Luis A. Diaz Jr. The author of a paper published Sunday in the New England Journal of Medicine describing the results, which was sponsored by the drug company GlaxoSmithKline, said he knew of no other study in which a treatment was completely obliterated in cancer. every patient.
“I believe this is the first time this has happened in the history of cancer,” Dr. Diaz said.
Dr. Alan P. Venook, a colorectal cancer specialist at the University of California, San Francisco, who was not affiliated with the study, said he also thought this was a first.
A complete remission in every single patient is “unheard-of,” he said.
These rectal cancer patients had grueling treatments – chemotherapy, radiation and, most likely, life-altering surgery that could result in bowel, urinary and sexual dysfunction. Some would need colostomy bags.
They entered the study thinking that, when it was over, they would undergo those procedures because no one really expected their tumors to disappear.
But they got a surprise: No further treatment was necessary.
“There were a lot of happy tears,” said Dr. Andrea Cercek, an oncologist at the Memorial Sloan Kettering Cancer Center and co-author of the paper, who presented at the annual meeting of the American Society of Clinical Oncology on Sunday.
Another surprise, Dr. Venook added, that none of the patients had clinically significant complications.
On average, one in five patients have some sort of adverse reaction to drugs like one of the patients took, dostarlimab, known as checkpoint inhibitors. The medication was given every three weeks for six months and cost about $ 11,000 per dose. It unmasks cancer cells, allowing the immune system to identify and destroy them.
While most adverse reactions are easily managed, as many as 3 percent to 5 percent of patients who take checkpoint inhibitors have more severe complications that, in some cases, result in muscle weakness and difficulty swallowing and chewing.
The absence of significant side effects, Dr. Venook said, meaning, “Either they didn’t treat enough patients or, somehow, these cancers are just plain different.”
In an editorial accompanying the paper, Dr. Hanna K. Sanoff of the University of North Carolina’s Lineberger Comprehensive Cancer Center, who was not involved in the study, called it “small but compelling.” She added, though, that it is not clear if the patients are cured.
“Very little is known about the duration of the time needed to find out if a clinical complete response to dostarlimab equates to cure,” Dr. Sanoff said in the editorial.
Dr. Kimmie Ng, a colorectal cancer specialist at Harvard Medical School, said that while the results were “remarkable” and “unprecedented,” they would need to be replicated.
The inspiration for the rectal cancer study came from a clinical trial Diaz led in 2017 that Merck, the drugmaker, funded. It is related to 86 people with metastatic cancer that originated in various parts of their bodies. But the cancers all shared a gene mutation that prevented the repair of damaged cells from DNA. These mutations occur in 4 percent of all cancer patients.
Patients in that trial took a Merck checkpoint inhibitor, pembrolizumab, for up to two years. Tumors shrank or stabilized in about one-third to one-half of the patients, and they lived longer. Tumors vanished in 10 percent of the trial’s participants.
That led Dr. Cercek and Dr. Diaz to ask: What if the drug were used much earlier in the course of the disease, before the cancer had a chance to spread?
They settled on a study of patients with locally advanced rectal cancer – tumors that had spread to the rectum and sometimes to the lymph nodes but not to other organs. Dr. Cercek had noticed that chemotherapy was not helping a portion of patients who had the same mutations that affected patients in the 2017 trial. Instead of shrinking during treatment, their rectal tumors grow.
Perhaps, Dr. Cercek and Dr. Diaz reasoned, immunotherapy with a checkpoint inhibitor will allow such patients to avoid chemotherapy, radiation and surgery.
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Dr. Diaz began asking companies that made checkpoint inhibitors if they would sponsor a small trial. They turned him down, saying the trial was too risky. He and Dr. Cercek wanted to give the drug to patients who could be cured with standard treatments. What the researchers were proposing might end up allowing the cancers to grow beyond the point where they could be cured.
“It’s very hard to alter the standard of care,” Dr. Diaz said. “The whole standard-of-care machine wants to do the surgery.”
Finally, a small biotechnology firm, Tesaro, agreed to sponsor the study. Tesaro was bought by GlaxoSmithKline, and Dr. Diaz said he had to remind the larger company that they were studying – company executives had all but forgotten about the small trial.
Their first patient was Sascha Roth, then 38. She first noticed some rectal bleeding in 2018 but otherwise felt fine – she is a runner and helps manage a family furniture store in Bethesda, Md.
During a sigmoidoscopy, she recalled, her gastroenterologist said, “Oh no. I was not expecting this! “
The next day, the doctor called Ms. Roth. He had the tumor biopsied. “It’s definitely cancer,” he told her.
“I’m completely melted down,” she said.
Soon, she was scheduled to start chemotherapy at Georgetown University, but a friend had insisted she first see Dr. Philip Paty at Memorial Sloan Kettering. Dr. Paty told her he had almost certain cancer included in her mutation that made it unlikely to respond well to chemotherapy. It turned out, though, that Ms. Roth was eligible to enter the clinical trial. If she had started chemotherapy, she wouldn’t have been.
Not expecting a complete response to dostarlimab, Ms. Roth had planned to move to New York for radiation, chemotherapy and, possibly, surgery after the trial ended. To preserve her fertility after the expected radiation treatment, she had her ovaries removed and put back under her ribs.
After the trial, Dr. Cercek gave her the news.
“We looked at your scans,” she said. “There is absolutely no cancer.” She did not need any further treatment.
“I told my family,” Ms. Roth said. “They didn’t believe me.”
But two years later, she still doesn’t have a trace of cancer.